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Increased pressure effects with maprotiline or TCA. Possibility of severe hypertensive reaction with MAOI.
Narrow Angle Glaucoma: The agents stimulate both alpha-1 and alpha-2 adrenergic receptors that can increase intraocular pressure.
Benign Prostatic Hyperplasia: Urinary difficulty may develop or worsen smooth muscle contraction in the bladder neck via stimulation of alpha-1 adrenergic receptors.
Cardiovascular Disease: These agents may produce positive chronotropic and inotropic effects via stimulation of beta-1 adrenergic receptors, possibility to severe hypertensive reaction.
Diabetes Mellitus: May occur slight increases in blood glucose concentrations.
